By David Y. Hwang
50 reports each Neurologist should still Know offers key experiences that form the present scientific perform of neurology. All neurologic subspecialties are coated, with a unique emphasis on neurocritical care and vascular neurology. for every research, a concise precis is gifted with an emphasis at the effects and barriers of the research, and its implications for perform. An illustrative scientific case concludes every one assessment, via short info on different correct stories. this is often the 1st ebook of its variety to give a set of the main influential medical trials in neurology which are particular sufficient for use on rounds, yet nonetheless simply digestible. it's a must-read for overall healthiness care pros and a person who desires to examine extra in regards to the facts in the back of medical practice.
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Extra info for 50 studies every neurologist should know
Study Intervention: After a patient was randomized to one of the 5 study medications, the treating clinician, aided by guidelines, decided the rate of titration, initial maintenance dose, and any subsequent increments or decrements. The goal was to control seizures with a minimum effective dose of drug as assigned. Follow-Up: 3 months, 6 months, 1 year, and at successive yearly intervals thereafter. Patients were followed up according to the principle of intention to treat. Endpoints: Primary outcomes: (1) time from randomization to treatment failure, and (2) time from randomization to achievement of a 1-year remission.
Glauser T et al. ILAE treatment guidelines: Evidence-based analysis of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures. Epilepsia. 2006;47(7):1094–1120. 6. Brodie MJ et al. Comparison of levetiracetam and controlled-release carbamazepine in newly diagnosed epilepsy. Neurology. 2007;68:402–4 08. 7. Baulac M et al. Comparison of the efficacy and tolerability of zonisamide and controlled release carbamazepine in the newly diagnosed partial epilepsy: a phase 3, randomized, double-blind, non-i nferiority trial.
2007;369(9566):1000–1015. Panayiotopoulos CP. Old versus new antiepileptic drugs: the SANAD study. Lancet. 2007;370:313–314. 3. Brodie MJ et al. Comparison of levetiracetam and controlled-release carbamazepine in newly diagnosed epilepsy. Neurology. 2007;68:402–4 08. 4. Saetre E et al. An international multicenter randomized double-blind controlled trial of lamotrigine and sustained-release carbamazepine in the treatment of newly diagnosed epilepsy in the elderly. Epilepsia. 2007;48:1292–1302.