Advances in the Treatment of Acute (Blastic) Leukemias by D. W. van Bekkum (auth.), Professor Georges Mathé (eds.)

By D. W. van Bekkum (auth.), Professor Georges Mathé (eds.)

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_..... · - ·.... 8 • • mz2ZI • · ' ' •........ l lllll! Asparaginase •-• Platelets/cu mm 0 - 0 WBC/cu mm ~ Cytosine arabinoside 4-4 Blasts/cu mm Fig. 2. anges in a man aged 60 with acute myeloblastic leukaemia treated with L-asparaginase (Bayer) Table 1. /ml 0 10 20 40 0 0 0 0 + + + + + + 0 0 0 0 0 0 Total 29 future almost certainly the enzyme will be best used in combination with other agents in this disease as weil. The development of resistance to the action of 1-asparaginase has been disappointing and has limited its usefulness in the treatment of leukaemia.

SCHWARTZ, M. , LEEPER, R. , CLARKSON, B. , GoLBEY, R. , KRAKOFF, I. , KARNOFSKY, D. , BuRCHENAL, J. : The toxicity of E. coli L-asparaginase in man. Cancer Feh. 1970. 15. , MuRPHY, M. : E. coli L-asparaginase in the treatment of leukemia and solid tumors in 131 children. Cancer Feh. 1970. 16. : Clinical results of treatment with E. coli L-asparaginase in adults with leukemia, Iymphoma, and solid tumors. Cancer Feh. 1970. 17. SoBIN, L. , Kmo, J. : A metabolic difference between two lines of Iymphoma 6C3HED cells in relation to asparagine.

CLARKSON, B. , LEEPER, R. , ScHWARTZ, M. , KrM, J. : Inhibition of leukemias by L-asparaginase. Cancer Res. 27, (Part 1) 2619-2631 (1967). BrsEL, H. : Criteria for the evaluation of response to treatment in acute leukemia. Blood 11, 676-677 (1956). HrLL, J. , HrLL, R. : L-asparaginase therapy for leukemia and other malignant neoplasms. J. Amer. med. Ass. 202, 882-888 (1967). HASKELL, c. , CANELLOS, G. , LEVENTHAL, B. , CARBONE, P. , SERPICK, A. , HANSEN, H. : Letter to the editor: L-asparaginase toxicity.

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